The role of sodium lactate injection is that sodium lactate injection is a commonly used electrolyte regulating drug in clinical practice, mainly composed of sodium lactate and injection water, and belongs to an alkaline solution. It is metabolized into bicarbonate in the human body, participating in acid-base balance regulation and supplementing sodium ions. The following explanation will be provided from the perspectives of pharmacological mechanisms, indications, application scenarios, precautions, and compatibility contraindications.
Pharmacological action 1 After correcting acidosis, sodium lactate enters the body and is metabolized by the liver to produce bicarbonate ions, neutralizing excess hydrogen ions in the blood and increasing blood pH. For acute metabolic acidosis (such as early diabetes ketoacidosis), it can quickly improve acidosis symptoms; Chronic renal insufficiency induced acidosis requires combined dialysis treatment. two Electrolyte supplementation: Sodium lactate injection contains approximately 167mg of sodium ions per 100ml, suitable for situations where sodium ions are lost due to diarrhea or burns. Sodium ions participate in regulating intracellular and extracellular osmotic pressure, maintaining neuromuscular excitability. three Adjuvant therapy, as one of the components of peritoneal dialysis fluid, helps to clear metabolic waste from the body; Combined use with blood transfusion can prevent citrate poisoning. Indications: Metabolic acidosis: Blood pH<7.35, HCO3 ⁻ concentration<22mmol/L Peritoneal dialysis solution configuration: Typically 40mmol/L Sodium deficiency: Serum sodium<135mmol/L with dehydration symptoms After cardiopulmonary resuscitation, acid-base imbalance: needs to be adjusted with blood gas analysis dosage and usage 1 The intravenous infusion rate for adult doses should not exceed 300ml/h. Mild acidosis requires 500-100ml per day, while severe acidosis requires a weight of 0.3ml/kg and should be diluted with 5% glucose before use. two Children's medication should be accurately calculated based on body weight, usually given at a rate of 2-3ml/kg, with the drip rate halved. Newborns should use with caution as it may cause high osmotic pressure. three Special adjustment
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Dose reduction of 30% for patients with renal insufficiency;
; Patients with abnormal liver function have decreased metabolic capacity and need to extend the dosing interval.
Taboos and caution: Do not use when there is pulmonary edema, alkalosis, or severe heart failure. Hypertensive patients need to monitor their blood pressure, and pregnant women should only use it when explicitly necessary. Compatibility taboos include: Calcium containing drugs (such as calcium gluconate) are prone to precipitate, while cardiac glycosides may exacerbate toxic reactions. Acidic solutions (vitamin C injection) can cause neutralization reactions and adverse reactions. Treatment 1 Hypernatremia manifests as thirst and confusion, requiring immediate cessation of use and administration of diuretics. two When metabolic alkalosis occurs and hand and foot convulsions occur, intravenous injection of calcium gluconate is administered. three Local redness and swelling caused by intravenous stimulation can be treated with external application of 50% magnesium sulfate. If the concentration is too high, it can be diluted to below 1.2%. Storage and management: Keep away from light below 25 ℃. Freezing can cause glass containers to break. After opening, use within 4 hours. Do not use when cloudy or discolored. It is recommended to use precision filtering equipment for infusion devices to prevent insoluble particles from entering blood vessels. In clinical applications, it has been found that excessive infusion may cause dehydration of brain cells, which requires cooperation with intracranial pressure monitoring. Under the trend of new balanced salt solutions (such as sodium acetate Ringer's solution) gradually replacing traditional sodium lactate, this drug still maintains an important position in the treatment of acidosis in patients with normal liver function. Electrolytes and arterial blood gas should be monitored every 4 hours during the medication process to ensure treatment safety.